Orexin receptors in GtoPdb v.2023.1

Orexin receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on [43]) are activated endogenous polypeptides orexin-A and orexin-B (also known hypocretin-1 -2; 33 28 aa) derived from a common precursor, preproorexin or orexin proteolytic cleavage some typical peptide modifications [117]. signaling has been associated with regulation of sleep wakefulness, reward addiction, appetite feeding, pain gating, stress response, anxiety depression. Currently receptor ligands in clinical use dual antagonists suvorexant lemborexant daridorexant, which used hypnotics, several OX2-selective under development. Multiple agonists development for treatment narcolepsy other disorders. 3D structures have solved [146, 144, 55, 126, 47, 109, 7, 145].